REGULATORY T CELLS
Inflammation in the brain, known as neuroinflammation, contributes to our health by removing debris and pathogens. However, in ALS too much neuroinflammation can harm brain cells, including motor neurons which allow the brain to communicate with muscles. The systematic administration of moderate anti-inflammatory drugs has met with little success in reducing various types of neurodegeneration, leading to a hunt for potent and selective inhibitors of the brains immune system.
Regulatory T cells are white blood cells which release anti-inflammatory cytokines and act as a ‘brake’ for the immune system. These cells recognise our own tissues and prevent them from being attacked by the rest of the immune system. When regulatory T cells fail to do this job the result is a variety of auto-immune diseases. The targeted and potent suppression of the immune system by regulatory T cells will be harnessed by Reflection Therapeutics to protect motor neurons from attack in ALS.
Halting neurodegeneration in ALS
PhD (or BSc with good laboratory experience) T cell immunologist with experience in primary cell culture, flow cytometry, transduction and activity assays. This is a paid short-term opportunity on a flexible, part-time basis that combines consultancy and laboratory work that can fit around your current commitments. Part and full-time interns will also be considered. Preferred start ASAP.
Gain industrial experience with a secondment from your post-doctoral position. Permanently-employed at a parent institution, this T cell scientist would co-apply for industrial fellowship grant with Reflection. This scheme involves secondment to Reflection Therapeutics on a full or part time basis allowing the applicant to gain valuable industrial experience in a fast moving start up, whilst continuing their post-doctoral academic projects.
For more information, please e-mail
Babraham Research Campus
Cambridge, CB22 3AT